An integrated multi-omics and network analysis of neutrophil differentiation from initial- to late-stage
Our work systematically investigates coordinated chromatin accessibility, TF binding, 3D genome-structure and transcriptional changes during neutrophil differentiation, especially at initialization. Our study highlights the sequential interplay between the initial changes of chromatin state, 3D genome organization and pioneer TF s such as CEBPA.
Authors
- Minglei Shi (ORCID: https://orcid.org/0000-0002-1108-4233)
- Panpan Cheng
- Longteng Wang (ORCID: https://orcid.org/0000-0002-0904-8081)
- Yingping Hou
- Wei Li (ORCID: https://orcid.org/0000-0002-2163-7903)
- Cuiyun Dou
- Qing Chen
- Kai Wang
- Tianchang Yang
Institutions
- University of Maryland, Baltimore (US)
- Children's National (US)
- George Washington University (US)
- Peking University (CN)
- National Center of Biomedical Analysis (CN)
- Ministry of Education (ET)
- Affiliated Hospital of Jining Medical University (CN)
Publication Details
- Journal
- Genome biology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1186/s13059-025-03902-1
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00