Clinically relevant somatic variants and genomic discordance between primary tumors and mediastinal lymph nodes in lung adenocarcinoma
Cox regression analysis demonstrated that the presence of co-mutations in MLN was a co-factor associated with poorer OS, while no significant associations were observed for PT variants. These findings highlight distinct genomic profiles between PT and MLN. Integrating the molecular profile of MLN into staging may improve prognostic accuracy and guide treatment decisions in LUAD patients.
Authors
- Luiza Capelozzi Vera
- Caroline Silvério Faria (ORCID: https://orcid.org/0000-0001-5272-2169)
- Leila Antonângelo (ORCID: https://orcid.org/0000-0002-8634-5100)
- Leslie Domenici Kulikowski (ORCID: https://orcid.org/0000-0003-2236-3956)
- Teresa Yae Takagaki (ORCID: https://orcid.org/0000-0003-2277-2100)
- Ilka Lopes Santoro (ORCID: https://orcid.org/0000-0002-9575-8361)
- Éllen Caroline Toledo do Nascimento (ORCID: https://orcid.org/0000-0002-2981-1419)
- Camila Machado Baldavira (ORCID: https://orcid.org/0000-0002-5364-7305)
- Murilo Castro Cervato (ORCID: https://orcid.org/0000-0001-8146-5798)
- Ricardo Mingarini Terra
- Viviane Rossi Figueiredo
- Tabatha Gutierrez Prieto
Institutions
- Universidade de Ribeirão Preto (BR)
- Instituto do Câncer do Estado de São Paulo (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Instituto do Coração (PT)
- Associação Paulista de Medicina (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Therapeutic Advances in Medical Oncology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1177/17588359251409007
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00