Amyloid‐related default mode network hyperconnectivity and longitudinal decline in network distinctiveness in preclinical Alzheimer's disease
Cognitively normal amyloid beta (Aβ)-positive (CN+) individuals showed stronger connectivity within the default mode network (DMN). CN+ individuals also showed weaker links between the DMN and other brain networks. Amyloid was not linked to connectivity changes in cognitively impaired adults. Higher DMN connectivity predicted broader network changes in CN+ individuals.
Authors
- Kwangslk Nho
- Yun‐Sang Lee
- Woo‐Jin Cha
- Hyejin Ahn
- Olaf Sporns
- Evgeny J. Chumin
- Min Soo Byun
- Dahyun Yi
- Shannon L. Risacher
- Dong Young Lee
- Gijung Jung
- Andrew J. Saykin
- Joon Hyung Jung
- Chul‐Ho Sohn
- Yu Kyeong Kim
- Koung Mi Kang
Institutions
- Seoul National University (KR)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Convergence Research Center for Diagnosis Treatment and Care System of Dementia (KR)
- Indiana University Bloomington (US)
- Chungbuk National University Hospital (KR)
- Indiana University School of Medicine
- Wake Forest University (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1002/alz.71025
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Seoul National University
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- National Institutes of Health