Ganoderic Acid A alleviates ulcerative colitis by inhibiting the interleukin17 signaling pathway via targeting retinoic acid-related orphan receptor alpha
Our findings disclose that GAA alleviated DSS-induced UC by inhibiting the IL-17 signaling pathway via targeting RORA to reduce inflammation. Our study suggests that GAA holds potential as a nutritional intervention for the prevention and treatment of UC.
Authors
- Yinni Chen
- T Liu
- Yifei Ye
- Shun Li
- Yu Hu
- Yuanli Chen
- Yiyang Cao
- Xiangnuo Han
- Shu Yang
- Xi Chen
Institutions
- Nanchang University (CN)
- Hefei University of Technology (CN)
- Jiangxi University of Technology (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Anhui Academy of Medical Sciences (CN)
- Peking University Shenzhen Hospital (CN)
- Jiang Xi Institute for Drug Control (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1016/j.jep.2026.121297
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00