Identification and validation of a glutamine metabolism-related gene signature as a diagnostic and therapeutic target in osteoarthritis through integrated multi-omics analysis
This study identifies a blood-based, multi-omics-derived gene signature that links localized joint pathology with systemic metabolic dysfunction in osteoarthritis. The signature offers a robust non-invasive diagnostic marker and reveals new opportunities for patient stratification and therapeutic development.
Authors
- Shasha Wang
- Bin Wu (ORCID: https://orcid.org/0000-0003-0742-380X)
- Wenfu Cao (ORCID: https://orcid.org/0000-0002-1816-5626)
- Jianping Gan
- Jinkun Liu
- Yang Lu
Institutions
- Jiangjin Central Hospital (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2026-01-30
- DOI
- https://doi.org/10.7717/peerj.20701
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00