Seizure and quality-of-life outcomes following responsive neurostimulation treatment for drug-resistant epilepsy in children and young adults
The authors' cohort of young patients with severe drug-resistant epilepsy from a variety of etiologies experienced comparable improvements in seizure control at 12 months to that reported in adults at 9 years. Patients also reported improvements in quality of life. These robust outcomes may be due to empirical targeting of patient-specific seizure networks and rapid escalation of therapy to higher treatment parameters.
Authors
- Ariana Philbin
- Alexandra L. Geffrey
- Nathan Sisterson
- Hunki Kwon
- Nora Daly
- Ziv M. Williams (ORCID: https://orcid.org/0000-0002-0017-0048)
- Wen Shi
- CJ Chu
- R. Mark Richardson
- Kristopher T. Kahle
Institutions
- Kennedy Krieger Institute (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Journal of Neurosurgery Pediatrics
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3171/2025.9.peds25200
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00