Multicenter Evaluation of Myocardial Flow Reserve as a Prognostic Marker for Mortality in <sup>13</sup> N-Ammonia PET Myocardial Perfusion Imaging
In this large multicenter cohort, MFR derived from <sup>13</sup>N-ammonia PET myocardial perfusion imaging is a strong, independent predictor of all-cause mortality, even in patients with normal perfusion. An MFR of ≤2.0 identifies elevated risk, while higher values are associated with improved survival. These findings support the routine integration of MFR to enhance risk stratification in patients with suspected or known coronary artery disease.
Authors
- R. Miller
- Mark H. Lemley (ORCID: https://orcid.org/0000-0002-1531-880X)
- Andrew Jeffrey Einstein (ORCID: https://orcid.org/0000-0003-2583-9278)
- Gilbert Ramı́rez (ORCID: https://orcid.org/0000-0001-7559-3646)
- Mark I. Travin
- Thomas L. Rosamond (ORCID: https://orcid.org/0009-0000-1417-8342)
- Na Song (ORCID: https://orcid.org/0000-0001-7793-570X)
- Erick Alexanderson
- Valerie Builoff
- Piotr J Slomka
- Leandro Slipczuk
- Isabel Carvajal-Juarez
- Marcelo F. Di Carli
- Samuel Wopperer
- Panithaya Chareonthaitawee
Institutions
- Cedars-Sinai Medical Center (US)
- Brigham and Women's Hospital (US)
- Albert Einstein College of Medicine (US)
- Mayo Clinic (US)
- NewYork–Presbyterian Hospital (US)
- University of Calgary (CA)
- Columbia University Irving Medical Center (US)
- Mayo Clinic in Arizona (US)
- University of Kansas Medical Center (US)
- Mayo Clinic in Florida (US)
- Instituto Nacional de Cardiología (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Circulation Cardiovascular Imaging
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1161/circimaging.125.018729
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00