Immunomodulatory properties of human dental pulp stromal cells: the role of IL-6/JAK/STAT3 pathway and PD-L1
Our study demonstrates the activation of the IL-6/PD-L1 axis in response to inflammatory conditions and underscores its potential significance in autoimmune diseases since a dysfunction of this mechanism could lead to the onset and progression of chronic inflammatory disorders.
Authors
- Giulia Orlandi (ORCID: https://orcid.org/0000-0001-9252-4028)
- Alessandra Pisciotta (ORCID: https://orcid.org/0000-0001-7818-0003)
- Cosimo De Bari (ORCID: https://orcid.org/0000-0002-5113-862X)
- Rosanna Di Tinco (ORCID: https://orcid.org/0000-0002-4531-8747)
- Gianluca Carnevale (ORCID: https://orcid.org/0000-0002-5348-5991)
- Laura Bertoni (ORCID: https://orcid.org/0000-0002-8994-8791)
- Stefania Croci (ORCID: https://orcid.org/0000-0002-8622-0439)
- Anke J. Roelofs (ORCID: https://orcid.org/0000-0001-8993-1984)
- Giulia Bertani (ORCID: https://orcid.org/0009-0009-0278-6215)
- Martina Bonacini (ORCID: https://orcid.org/0000-0002-6830-6781)
- Alessandro Rossi (ORCID: https://orcid.org/0000-0002-6719-3324)
- Elisa Pignatti (ORCID: https://orcid.org/0000-0003-3527-3132)
- Carlo Salvarani
Institutions
- University of Modena and Reggio Emilia (IT)
- Edinburgh Cancer Research (GB)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fimmu.2026.1713704
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00