Rats exposed to a low resource environment in early life display sex differences in blood pressure, autonomic activity, and brain and kidney pro-inflammatory markers during adulthood
Adult LBN males have elevated BP, due to increased SNA, while LBN females may be protected from increased BP due to a simultaneous increase in SNA and PNA. The reduction in IL-17 and TNF-α in LBN males may serve as a compensatory mechanism to lower BP. This study provides insights into sex differences in BP for adults who experienced childhood poverty.
Authors
- Angie Castillo (ORCID: https://orcid.org/0009-0009-8108-8051)
- Jonna Smith
- Jessica L. Bolton (ORCID: https://orcid.org/0000-0002-8872-4999)
- Luis M. Colón-Pérez (ORCID: https://orcid.org/0000-0001-8918-2418)
- Kylie Jones
- Allison Burkes
- Faith Femi-Ogunyemi
- Savanna Smith
- Mark Cunningham
- Ahfiya Howard
Institutions
- University of North Texas (US)
- University of North Texas Health Science Center (US)
- Georgia State University (US)
- East Texas A&M University (US)
- Texas College (US)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1186/s13293-026-00842-8
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 0.00