Hereditary diffuse gastric cancer: between underdiagnosis and overtreatment: a case series
This case series underscores the clinical heterogeneity of HDGC and the critical role of timely genetic testing, family history assessment, and early prophylactic gastrectomy in high-risk carriers. A multidisciplinary approach integrating clinical genetics, surgery, and endoscopic expertise is essential to optimize risk-reducing strategies and outcomes in HDGC.
Authors
- Alessandro Cappellani (ORCID: https://orcid.org/0000-0002-9113-2396)
- Andrea Sebastiano Cavallaro (ORCID: https://orcid.org/0000-0002-0311-5191)
- Paolo Di Mattia (ORCID: https://orcid.org/0000-0002-3429-7880)
- Kenya Tiralongo (ORCID: https://orcid.org/0009-0003-0783-7241)
- Luigi La Via
- Giorgio Giannone
- Antonio Zanghì
- Giorgio Graziano
- Filippo Sanfilippo
Institutions
- Mediterranean University (ME)
- Policlinico Universitario di Catania (IT)
- Ospedali Riuniti Umberto I (IT)
Publication Details
- Journal
- Frontiers in Surgery
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fsurg.2026.1732442
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00