Neurotransmitters involvement in the formation of abnormal uterine bleeding against different body weight

Background. The problem of hormonal relationships in endocrine-dependent gynecological pathology has not lost its relevance today, as it is a key link in deciphering the pathogenesis of these diseases. Purpose – of the study was to determine the role of catecholamines, serotonin and histamine in the formation of abnormal uterine bleeding at different body weights. Materials and Methods. 125 patients with abnormal uterine bleeding aged 11 to 17 years were under observation. Depending on body mass index, they were divided into three groups. First group consisted of 19 patients with a body weight deficit (body mass index = 16.48 ± 0.20), second group included 75 patients with physiological body mass index (19.58 ± 0.17), and three group – 31 girls with excess body weight (body mass index = 27.0 ± 0.74). The complex of laboratory examinations included the determination of the levels of adrenaline, noradrenaline in daily urine, serotonin, histamine, cortisol in blood serum. Results. Abnormal uterine bleeding occurs against the background of significant changes in the content of adrenaline, noradrenaline, serotonin, histamine which indicate the activation of the sympatho-adrenal system and the production of serotonin and histamine. An increase in the adrenaline/noradrenaline index indicates the predominance of the hormonal link in the activity of the sympatho-adrenal system of this contingent of patients. It has been proven that patients with abnormal uterine bleeding with different body weights have certain features in the content of neurotransmitters, which indicate that the monoaminergic control of the course of abnormal uterine bleeding is influenced by the body weight gained at the time of the appearance of uterine bleeding. A mathematical model has been created that confirms the existence of differences in the levels and interaction of neurotransmitters in abnormal uterine bleeding, which depend on the distribution of adolescent girls with abnormal uterine bleeding into groups depending on the body mass index at which abnormal uterine bleeding occurs. Conclusions. Abnormal uterine bleeding occurs against the background of dissociation of the activity of the sympatho-adrenal system, the content of serotonin, histamine. With physiological body weight and its deficiency, both stress-providing (daily urinary excretion of adrenaline, noradrenaline increases) and stress-limiting (the level of S in the blood increases). With excess body weight, the reaction of the sympatho-adrenal system is much lower, which may indicate reduced adaptive resources to a stressful situation – the occurrence of uterine bleeding.