A switch from α5β1 to αvβ3 integrin activity contributes to the development of a profibrotic mesenchymal phenotype in trabecular meshwork cells
These studies suggest that crosstalk between α5β1 and αvβ3 integrin signaling controls expression of αSMA mRNA and protein levels and that β3 integrins may play a role in the development of the fibrogenic phenotype in TM cells and associated with POAG.
Authors
- Jennifer A. Faralli
- Donna M. Peters (ORCID: https://orcid.org/0000-0002-1303-7027)
- Mark S. Filla
- Kassidy L. Johns
- Neelima Shah
- Kate E. Keller
Institutions
- University of Wisconsin–Madison (US)
- Oregon Health & Science University (US)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fcell.2025.1730542
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Wisconsin Carbone Cancer Center
- National Institutes of Health