Preclinical amyloid pathology is associated with anxiety but not depression in cognitively normal older adults: Evidence for differential neuropsychiatric pathways
Preclinical amyloid pathology directly associates with subclinical anxiety but only indirectly with depression through subjective stress, suggesting distinct neuropsychiatric pathways in early AD that could inform detection strategies.
Authors
- Ipsit V. Vahia (ORCID: https://orcid.org/0000-0002-0282-640X)
- Regan Patrick (ORCID: https://orcid.org/0000-0002-6421-2665)
- Sara L. Weisenbach (ORCID: https://orcid.org/0000-0002-5330-4038)
- Clara Beck
- Jonathan Vogelgsang
Institutions
- Universität Hamburg (DE)
- McLean Hospital (US)
- Massachusetts General Hospital (US)
- University Medical Center Hamburg-Eppendorf (DE)
- Dermatologikum Hamburg (DE)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1016/j.tjpad.2026.100497
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00