First-line FOLFOXIRI-based Chemotherapy for Unresectable Metastatic Colorectal Cancer: Real-world Outcomes, Safety, and Conversion Surgery
In Japanese practice, first-line FOLFOXIRI achieved substantial disease control and clinically meaningful survival with manageable toxicity. R0 conversion was achieved in the subset with longer survival. A conversion-oriented triplet induction strategy may be considered for rectal cancer without peritoneal metastasis, irrespective of <i>RAS</i> status.
Authors
- Akira Inoue
- Kou Takachi
- Ryohei Wada
- Yusuke Matsuura (ORCID: https://orcid.org/0000-0002-1469-8329)
- Ryutaro Wada
- Masataka Fujiwara
- Y U Takeda
- Sakae Maeda
- Hirofumi Ota
- Koji Munakata
- Kosuke Nishihara
Institutions
- Ikeda Municipal Hospital (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2026-01-30
- DOI
- https://doi.org/10.21873/anticanres.18003
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00