Tissue-Free Circulating Tumor DNA Assay and Patient Outcome in a Phase III Trial of FOLFOX-Based Adjuvant Chemotherapy (Alliance N0147)

Evaluation of ctDNA in resected stage III CC using a tissue-free assay provided robust and independent prognostic value. Higher ctDNA burden, dMMR, and specific mutations defined poor prognostic groups among ctDNA-positive patients.

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Publication Details

Journal
Journal of Clinical Oncology
Published
2026-01-30
DOI
https://doi.org/10.1200/jco-25-02086
Citations
1
Primary Topic
Cancer Genomics and Diagnostics
Type
article
Field-Weighted Citation Impact
24.82
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article

Tissue-Free Circulating Tumor DNA Assay and Patient Outcome in a Phase III Trial of FOLFOX-Based Adjuvant Chemotherapy (Alliance N0147)

Aaron Hardin, Thereasa A. Rich, Diana Segovia, Nalin Sharma et al.
1 citations
Journal of Clinical Oncology
Cancer Genomics and Diagnostics
24.82
article

Tissue-Free Circulating Tumor DNA Assay and Patient Outcome in a Phase III Trial of FOLFOX-Based Adjuvant Chemotherapy (Alliance N0147)

Aaron Hardin, Thereasa A. Rich, Diana Segovia, Nalin Sharma, Qian Shi, Frank A. Sinicrope
article en
1 citations

Abstract

Evaluation of ctDNA in resected stage III CC using a tissue-free assay provided robust and independent prognostic value. Higher ctDNA burden, dMMR, and specific mutations defined poor prognostic groups among ctDNA-positive patients.

Journal of Clinical Oncology
Mayo Clinic (US), Guardant (United States) (US), Mayo Clinic in Arizona (US), Mayo Clinic in Florida (US)
Good health and well-being
Openalex Percentile: Top 1%
Cancer Genomics and Diagnostics
24.82
DOISourceOpenAlex
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Tissue-Free Circulating Tumor DNA Assay and Patient Outcome in a Phase III Trial of FOLFOX-Based Adjuvant Chemotherapy (Alliance N0147) — Aaron Hardin, Thereasa A. Rich, et al. · Journal of Clinical Oncology (2026) | TGRS Research Map | TGRS