Sex‐specific acceleration of Alzheimer's pathogenesis by chronic sleep‐deprivation
Chronic sleep disruption accelerates the pathological cascade of Alzheimer's, including cognitive impairment and Alzheimer's pathology in a sex-dependent manner. This work enhances our understanding of the sleep-stress-Alzheimer's relationship, including sex-based differences, and may point to a novel therapeutic avenue to limit Alzheimer's progression.
Authors
- S. Abid Hussaini
- Christopher D. Morrone
- Dominic Simpson (ORCID: https://orcid.org/0000-0001-5219-1302)
- Darcy Wear
- Wai Haung Yu
- Fang Liu
Institutions
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Cornell University (US)
- Burke Medical Research Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1002/alz.71099
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- BrightFocus Foundation
- Ministry of Colleges and Universities
- National Institutes of Health
- Natural Sciences and Engineering Research Council of Canada