Splicing Factor SF3B4 Suppresses Pancreatic Cancer Growth and Migration by Inhibiting Autophagy

SF3B4 is a context-dependent splicing factor that functions as a tumor suppressor in PDAC by regulating autophagy and redox homeostasis. Targeting the SF3B4-autophagy-ROS axis may represent a promising strategy to suppress PDAC progression and overcome chemoresistance.

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Publication Details

Journal
Anticancer Research
Published
2026-01-30
DOI
https://doi.org/10.21873/anticanres.17983
Primary Topic
Autophagy in Disease and Therapy
Type
article
Field-Weighted Citation Impact
0.00
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article

Splicing Factor SF3B4 Suppresses Pancreatic Cancer Growth and Migration by Inhibiting Autophagy

S. W. Choi, JIYOON SEO, SEUNG MIN JEONG
Anticancer Research
Autophagy in Disease and Therapy
article

Splicing Factor SF3B4 Suppresses Pancreatic Cancer Growth and Migration by Inhibiting Autophagy

S. W. Choi, JIYOON SEO, SEUNG MIN JEONG
article en

Abstract

SF3B4 is a context-dependent splicing factor that functions as a tumor suppressor in PDAC by regulating autophagy and redox homeostasis. Targeting the SF3B4-autophagy-ROS axis may represent a promising strategy to suppress PDAC progression and overcome chemoresistance.

Anticancer ResearchVol. 46(2)
Catholic University of Korea (KR)
Openalex Percentile: Top 71%
Autophagy in Disease and Therapy
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Splicing Factor SF3B4 Suppresses Pancreatic Cancer Growth and Migration by Inhibiting Autophagy — S. W. Choi, JIYOON SEO, et al. · Anticancer Research (2026) | TGRS Research Map | TGRS