A pathologically diagnosed multinodular and vacuolating neuronal tumor without typical multiple nodules: a case report

Multinodular and vacuolating neuronal tumors (MVNT) are glioneuronal and neuronal tumors classified as grade 1 in the 2021 World Health Organization classification of central nervous system tumors. These tumors are characterized by multiple nodules located between the deep cortex and subcortical white matter. Typically, patients are diagnosed radiologically and do not require treatment. This report describes a rare case of pathologically confirmed MVNT with radiological findings similar to those of low-grade glioma. Moreover, we highlight radiological features useful for differentiating MVNT from low-grade glioma.

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Publication Details

Journal
Frontiers in Radiology
Published
2026-01-30
DOI
https://doi.org/10.3389/fradi.2026.1718759
Primary Topic
Glioma Diagnosis and Treatment
Type
article
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article

A pathologically diagnosed multinodular and vacuolating neuronal tumor without typical multiple nodules: a case report

Takashi Sasayama, Keiichiro Uehara, Masamitsu Nishihara, Tomoaki Harada et al.
Frontiers in Radiology
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A pathologically diagnosed multinodular and vacuolating neuronal tumor without typical multiple nodules: a case report

Takashi Sasayama, Keiichiro Uehara, Masamitsu Nishihara, Tomoaki Harada, Hiroaki Nagashima, Ryota Kitano, Kazuhiro Tanaka
article en

Abstract

Multinodular and vacuolating neuronal tumors (MVNT) are glioneuronal and neuronal tumors classified as grade 1 in the 2021 World Health Organization classification of central nervous system tumors. These tumors are characterized by multiple nodules located between the deep cortex and subcortical white matter. Typically, patients are diagnosed radiologically and do not require treatment. This report describes a rare case of pathologically confirmed MVNT with radiological findings similar to those of low-grade glioma. Moreover, we highlight radiological features useful for differentiating MVNT from low-grade glioma.

Frontiers in RadiologyVol. 6
Kobe City Nishi-Kobe Medical Center (JP), Kobe University (JP)
Good health and well-being
Openalex Percentile: Top 73%
Glioma Diagnosis and Treatment
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