Enhanced immunogenicity of the Brucella A19 ΔbtpB mutant leads to accelerated clearance in the host
Our research demonstrates that Δ<i>btpB</i> leads to a reduced survival capacity of <i>Brucella</i>, while enhancing its immunogenicity. This suggests <i>btpB</i> is an important target for the prevention of <i>Brucella</i>.
Authors
- Qing Lü (ORCID: https://orcid.org/0000-0001-5350-776X)
- Ting Tang (ORCID: https://orcid.org/0000-0001-6209-1794)
- Yuan Yu (ORCID: https://orcid.org/0000-0001-5453-2377)
- A. Wang
- Gaowa Wudong
- Yaping Jin (ORCID: https://orcid.org/0000-0003-1772-2862)
- Wei Liu
- Xuan Bu
- Yunyi Zhai
- Dong Zhou
Institutions
- Ministry of Agriculture & Farmers Welfare (IN)
- Ministry of Education (IR)
- Ministère de l'Agriculture et de la Souveraineté alimentaire (FR)
- Northwest A&F University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fimmu.2026.1747903
- Primary Topic
- Brucella: diagnosis, epidemiology, treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00