Symptomatic sinus bradycardia during the recovery phase of high-altitude pulmonary edema: a case report

This case report describes a 28-year-old healthy male who developed high-altitude pulmonary edema (HAPE) after a rapid ascent. While his condition improved with standard therapy (including corticosteroids, diuretics, and supplemental oxygen), he developed symptomatic sinus bradycardia (heart rate nadir: 37 bpm) 2 days after discontinuation of these medications. The bradycardia resolved with intravenous potassium supplementation and fluid resuscitation, and his heart rate recovered to 59 bpm. This case highlights that a rebound in vagal tone and steroid withdrawal may contribute to severe bradycardia during the HAPE recovery phase, warranting heightened clinical vigilance.

Authors

Institutions

Publication Details

Journal
Frontiers in Medicine
Published
2026-01-30
DOI
https://doi.org/10.3389/fmed.2026.1754071
Primary Topic
High Altitude and Hypoxia
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Symptomatic sinus bradycardia during the recovery phase of high-altitude pulmonary edema: a case report

Jiale Xie, Weiping Li, Zhibiao Cai, Jia Luan et al.
Frontiers in Medicine
High Altitude and Hypoxia
article

Symptomatic sinus bradycardia during the recovery phase of high-altitude pulmonary edema: a case report

Jiale Xie, Weiping Li, Zhibiao Cai, Jia Luan, Haijun Miao
article en

Abstract

This case report describes a 28-year-old healthy male who developed high-altitude pulmonary edema (HAPE) after a rapid ascent. While his condition improved with standard therapy (including corticosteroids, diuretics, and supplemental oxygen), he developed symptomatic sinus bradycardia (heart rate nadir: 37 bpm) 2 days after discontinuation of these medications. The bradycardia resolved with intravenous potassium supplementation and fluid resuscitation, and his heart rate recovered to 59 bpm. This case highlights that a rebound in vagal tone and steroid withdrawal may contribute to severe bradycardia during the HAPE recovery phase, warranting heightened clinical vigilance.

Frontiers in MedicineVol. 13
People's Liberation Army 401 Hospital (CN)
Good health and well-being
Openalex Percentile: Top 68%
High Altitude and Hypoxia
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.