The <scp>129S1</scp> / <scp>SvImJ</scp> Mouse Strain Is Resistant to the Effects of Early Embryonic Alcohol and Other Sonic Hedgehog Inhibitors

129S1 embryos have higher expression of key Shh pathway genes and low apoptosis after alcohol, which may contribute to the alcohol-resistant phenotype seen in the 129S1/SvImJ strain, adding to the understanding of protective genetic factors in alcohol teratogenesis.

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Publication Details

Journal
Birth Defects Research
Published
2026-01-30
DOI
https://doi.org/10.1002/bdr2.70020
Primary Topic
Prenatal Substance Exposure Effects
Type
article
Field-Weighted Citation Impact
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article

The 129S1 / SvImJ Mouse Strain Is Resistant to the Effects of Early Embryonic Alcohol and Other Sonic Hedgehog Inhibitors

Scott Parnell, Eric W. Fish, Ruby L. Lapham
Birth Defects Research
Prenatal Substance Exposure Effects
article

The 129S1 / SvImJ Mouse Strain Is Resistant to the Effects of Early Embryonic Alcohol and Other Sonic Hedgehog Inhibitors

Scott Parnell, Eric W. Fish, Ruby L. Lapham
article en

Abstract

129S1 embryos have higher expression of key Shh pathway genes and low apoptosis after alcohol, which may contribute to the alcohol-resistant phenotype seen in the 129S1/SvImJ strain, adding to the understanding of protective genetic factors in alcohol teratogenesis.

Birth Defects ResearchVol. 118(2)
University of North Carolina at Chapel Hill (US)
Good health and well-being
Openalex Percentile: Top 73%
Prenatal Substance Exposure Effects
DOIOpen Access PDFOpenAlex
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