Alternative splicing regulates PACC1 function and promotes acidosis-induced cytotoxicity
Alternative splicing governs PACC1 channel trafficking and function. Isoform-specific behavior suggests distinct roles for PACC1 variants in cell development and responses to acid stress, particularly within the nervous system.
Authors
- Serena Tamburro
- P. Scudieri
- Giulia Gorrieri (ORCID: https://orcid.org/0000-0001-8550-503X)
- Ilaria Musante (ORCID: https://orcid.org/0000-0003-2949-8714)
- Floriana Guida
- Ramona Tallone (ORCID: https://orcid.org/0009-0007-9458-8851)
- Francesca Antonini (ORCID: https://orcid.org/0000-0002-4469-8522)
- Federico Zara
- Niccolò Callegari
Institutions
- Istituto Giannina Gaslini (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fcell.2025.1754079
- Primary Topic
- Ion Transport and Channel Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute