SUMOylation machinery protein, PIAS4 role in breast cancer cell proliferation and drug sensitivity
PIAS4 expression level plays a role in breast cancer cell survival, invasiveness, and chemoresistance, partly by altering anti-apoptotic pathways. These findings position PIAS4 as a potential biomarker and therapeutic target for overcoming resistance to anthracycline-based therapies in breast cancer.
Authors
- Mohamed M. A. E. L. Salem
- Sriharsha Kantamneni (ORCID: https://orcid.org/0000-0002-3750-9447)
- Ritchie Williamson (ORCID: https://orcid.org/0000-0003-4278-0909)
- Mohammed A. M. Salih
- Muhammad Ali Shahid
- Hussein A. S. Elrewey
Institutions
- University of Bradford (GB)
- Leeds Trinity University (GB)
- University of Toyama (JP)
- Bradford College, England (GB)
Publication Details
- Journal
- Molecular Biology Reports
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1007/s11033-025-11423-0
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00