Acute kidney injury is a major mediator of intra-abdominal pressure-related mortality in critically ill patients: a longitudinal analysis

Severe acute kidney injury (stage 3) is a key mediator of IAH-related mortality in critically ill patients, whereas KRT was associated with a protective effect. The absence of an important mediating role for respiratory parameters suggests that the relationship between IAH and mortality is driven primarily by renal mechanisms. However, pulmonary impairment may not have been fully captured by the variables studied, particularly in a retrospective study. Unmeasured aspects of pulmonary dysfunction could still contribute to mortality.