Early Behavioral and Cognitive Changes in Patients With Pathologically Confirmed Alzheimer Disease, Lewy Body Dementia, and Mixed Dementia
These findings reveal distinct clinical subtypes that cut across traditional pathological boundaries, emphasizing the need to incorporate both cognitive and behavioral features into early dementia characterization. This multidimensional approach can improve guide personalized prognosis and care planning and enhance clinical trial design by considering disease heterogeneity. The study supports integrated clinical profiling as important factor in robust evaluation of dementia outcomes.
Authors
- Wen Tang (ORCID: https://orcid.org/0000-0003-3710-9029)
- Hao Feng
- Yiming Chen (ORCID: https://orcid.org/0000-0002-1501-5550)
- Jagan A Pillai
- Hongke Wu
- James B. Leverenz
- Lijun Zhang
- Ming Wang
- Aaron Bonner-Jackson
- Chixiang Chen
Institutions
- University of Maryland, Baltimore (US)
- University of Washington (US)
- Lou Ruvo Brain Institute (US)
- VA Puget Sound Health Care System (US)
- The Neurological Institute (US)
- Case Western Reserve University (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Neurology Open Access
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1212/wn9.0000000000000055
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00