Uridine diphosphate drives myeloid differentiation and functional reprogramming through dynamic transcriptional network
Our findings identify UDP as a potent immunomodulatory metabolite that restricts monocyte proliferation while promoting differentiation into dendritic-like cells with enhanced phagocytic capacity. UDP engages complex transcriptional programs that integrate innate activation with adaptive immune regulation, highlighting its potential role in immune homeostasis and inflammation control.
Authors
- Debora Gentile (ORCID: https://orcid.org/0000-0003-3541-1830)
- Camillo Palmieri (ORCID: https://orcid.org/0000-0001-6707-4723)
- Costanza Maria Cristiani (ORCID: https://orcid.org/0000-0002-7811-2083)
- Raffaella Gallo (ORCID: https://orcid.org/0000-0003-1234-5551)
- Ilenia Aversa (ORCID: https://orcid.org/0000-0003-4721-6792)
- Gianluca Santamaria (ORCID: https://orcid.org/0000-0001-9284-7492)
- Emilio Straface
- Alessandro Arcucci
- Giuseppe Fiume (ORCID: https://orcid.org/0000-0002-5414-6190)
- Antonio Abatino (ORCID: https://orcid.org/0009-0005-8932-2501)
- Francesco Albano (ORCID: https://orcid.org/0000-0001-7926-6052)
- Arianna Pastore (ORCID: https://orcid.org/0000-0002-2436-658X)
- Caterina Giordano (ORCID: https://orcid.org/0000-0001-8681-8230)
- Geppino Falco (ORCID: https://orcid.org/0000-0001-6193-7233)
- Marilena Celano
- Claudia Veneziano
- Lisa Isdraele Romano
Institutions
- Magna Graecia University (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fimmu.2026.1743389
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00