Systemic Embolic Events in Atrial Fibrillation: An Individual Patient Data Meta-analysis of 71 683 Participants Randomized to NOAC Versus Warfarin
In this large individual patient data meta-analysis, non-vitamin K antagonist oral anticoagulants significantly reduced the risk of SEE compared with warfarin. Although SEEs were approximately one-tenth as frequent as IS, they were associated with comparable mortality and substantial morbidity.
Authors
- Anthony Carnicelli (ORCID: https://orcid.org/0000-0002-9805-4562)
- Bram J. Geller (ORCID: https://orcid.org/0000-0002-0767-5102)
- Robert P. Giugliano (ORCID: https://orcid.org/0000-0003-4110-7675)
- E. M. Antman
- Christian T. Ruff
- M I and Ansari Patel
- Giorgio E. M. Melloni
- Michael G. Palazzolo
- Eugene Braunwald
- John Eikelboom
- Lars Wallentin
Institutions
- Uppsala University (SE)
- Maine Medical Center (US)
- Uppsala University Hospital (SE)
- Medical University of South Carolina (US)
- Clinical Research Institute (US)
- Maine Medical Center (US)
- Thrombolysis in Myocardial Infarction Study Group (US)
- McMaster University (CA)
Publication Details
- Journal
- Circulation
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1161/circulationaha.125.075275
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00