Molecular features of prenylated (iso)flavonoids from Fabaceae in relation to their potential NorA inhibition in Staphylococcus aureus
In our study, we provide, for the first time, predictive QSAR models of prenylated (iso)flavonoids as potential NorA inhibitors and propose two potential leads based on this family of plant-derived compounds. Future research on the specificity and validation of prenylated (iso)flavonoids as NorA inhibitors is required.
Authors
- Marina Ika Irianti (ORCID: https://orcid.org/0000-0002-4792-5292)
- Jean-Paul Vincken
- Janniek Henrieke Ritsema
- Jos Hageman
- Carla Araya-Cloutier
Institutions
- Zimmer Biomet (Netherlands) (NL)
- University of Indonesia (ID)
- Wageningen University & Research (NL)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fphar.2025.1715533
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek