Predictors of initiating high-efficacy vs. platform therapies as first-line disease-modifying treatment in multiple sclerosis

First-line use of heDMTs in Saudi Arabia has increased substantially over recent years, particularly among patients with cerebellar onset. While disability outcomes were similar between treatment groups, initiating heDMTs conferred clear advantages in persistence and tolerability. These findings reinforce the paradigm shift toward early intensive MS management and highlight the need for broader access and guideline-driven implementation of heDMTs in the region.

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Publication Details

Journal
Frontiers in Neurology
Published
2026-01-30
DOI
https://doi.org/10.3389/fneur.2026.1738815
Primary Topic
Multiple Sclerosis Research Studies
Type
article
Field-Weighted Citation Impact
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article

Predictors of initiating high-efficacy vs. platform therapies as first-line disease-modifying treatment in multiple sclerosis

Thamer Saad Alhowaish, Yaser Al Malik, Fahad Khalid Almubarak, Mezyed Fahad Alghanim et al.
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article

Predictors of initiating high-efficacy vs. platform therapies as first-line disease-modifying treatment in multiple sclerosis

Thamer Saad Alhowaish, Yaser Al Malik, Fahad Khalid Almubarak, Mezyed Fahad Alghanim, Nouf AlTuwaijri, Feras Alanazi, Khalid Bin Aziz, Raghad Alanazi, Saleh Alkhreigi, Faisal Aleisa
article en

Abstract

First-line use of heDMTs in Saudi Arabia has increased substantially over recent years, particularly among patients with cerebellar onset. While disability outcomes were similar between treatment groups, initiating heDMTs conferred clear advantages in persistence and tolerability. These findings reinforce the paradigm shift toward early intensive MS management and highlight the need for broader access and guideline-driven implementation of heDMTs in the region.

Frontiers in NeurologyVol. 17
Northern Border University (SA), King Saud bin Abdulaziz University for Health Sciences (SA), Princeton University (US), King Abdullah International Medical Research Center (SA), National Guard Health Affairs (SA)
Good health and well-being
Openalex Percentile: Top 74%
Multiple Sclerosis Research Studies
DOIOpen Access PDFOpenAlex
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Predictors of initiating high-efficacy vs. platform therapies as first-line disease-modifying treatment in multiple sclerosis — Thamer Saad Alhowaish, Yaser Al Malik, et al. · Frontiers in Neurology (2026) | TGRS Research Map | TGRS