Secretory versus non-secretory hepatocellular carcinoma: associations of serum AFP, CEA and CA19-9 levels with clinical presentation, metastatic patterns, and survival
AFP and CA19-9 elevations were associated with more advanced disease and poorer survival outcomes. We emphasize the importance of integrating tumor marker levels with imaging and histopathology for a multimodal diagnostic approach. Further research is needed to validate these associations to better define the role of biomarkers in HCC management.
Authors
- Mark Wayne Sonderup (ORCID: https://orcid.org/0000-0001-7128-8329)
- M. Bernon (ORCID: https://orcid.org/0000-0002-7967-8548)
- U. Kotze (ORCID: https://orcid.org/0000-0003-1405-474X)
- Muhammad Emmamally (ORCID: https://orcid.org/0009-0005-2148-685X)
- J. Krige
- E G Jonas
- Rufaida Khan
- Dr Sanju Sobnach
- C. Wendy Spearman
Institutions
- Groote Schuur Hospital (ZA)
Publication Details
- Journal
- Journal of Circulating Biomarkers
- Published
- 2026-01-29
- DOI
- https://doi.org/10.33393/jcb.2026.3637
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Cape Town