Understanding mechanisms of reduced cefiderocol susceptibility in <i>pvdS</i> and <i>fecI</i> mutants of <i>Pseudomonas aeruginosa</i>
These data highlight different mechanisms by which P. aeruginosa attempts to evade the action of cefiderocol by exploiting the complexities of iron haemostasis in bacteria. The absence of such mutants in the clinic suggests that such mutations may be detrimental for P. aeruginosa to survive in the clinical environment.
Authors
- Masatomo Rokushima (ORCID: https://orcid.org/0009-0000-6999-3854)
- Hideki Maki (ORCID: https://orcid.org/0000-0003-1769-550X)
- Takumi Adachi
- Miki Takemura (ORCID: https://orcid.org/0000-0002-1949-5555)
- Naoki Ishibashi
- Rio Nakamura (ORCID: https://orcid.org/0000-0003-0327-8932)
- Yoshinori Yamano (ORCID: https://orcid.org/0000-0002-7860-8863)
- Ryuta Ishii (ORCID: https://orcid.org/0000-0003-0326-7299)
- Yoshino Ishioka
- Takafumi Sato (ORCID: https://orcid.org/0000-0001-6843-2377)
- Boudewijn L M DeJonge
- Christopher Longshaw
- Dai Miyagawa
- Miho Kuroiwa
Institutions
- Shionogi (United States) (US)
- Futaba (Japan) (JP)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1093/jac/dkag004
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shionogi