Affinity selection mass spectrometry (AS-MS) as a tool to accelerate drug discovery efforts

AS-MS is a unique biophysical binding assay that does not rely on labels and can specifically detect binders from large pools of potential ligands based on molecular weight. There is still significant room for growth in areas of impact that will be driven by decreases in separation time and a move toward equilibrium conditions during separation. Increased use for driving rapid structure-activity relationships (SAR) has potential to decrease project cycle times in lead identification and optimization.