Peptide OH‐CATH30 Mitigates Cachexia‐Induced Muscle Atrophy via Modulation of TLR4‐Associated Inflammation
Our findings underscore the critical role of TLR4 signalling in cachexia-associated muscle wasting across different disease contexts and demonstrate the efficacy of OH-CATH30, a TLR4 inhibitor, in alleviating muscle atrophy in various cachexia models.
Authors
- Wen‐Hui Lee (ORCID: https://orcid.org/0000-0003-2621-5782)
- Lin Zeng (ORCID: https://orcid.org/0000-0003-1544-5582)
- M Zhang
- Yunling Wen
- Chunping Huang
- Yang Xiang
- Xinqiang Lan
- Caifen Guo
- Jian Li
- Shengan Li
- Qiquan Wang
- Dongqin Zhang
- Limin Zhao
- Hao Ke
- Mengqi Yang
- Xiang Wang
Institutions
- Kunming University (CN)
- Guiyang Medical University (CN)
- Kunming Institute of Zoology (CN)
- Peking University (CN)
- Kunming Medical University (CN)
- Beijing Jishuitan Hospital (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Institute of Aging (CA)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1002/jcsm.70195
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Guizhou Province
- National Natural Science Foundation of China
- Nanchang University