Directional replicability: When can the factor of two be omitted

Directional replicability addresses the question of whether an effect studied across <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>n</mml:mi></mml:math> independent studies is present with the same direction in at least <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>r</mml:mi></mml:math> of them, for <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>r</mml:mi> <mml:mo>≥</mml:mo> <mml:mn>2</mml:mn></mml:math> . When the expected direction of the effect is not specified in advance, the state of the art recommends assessing replicability separately by combining one-sided <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>p</mml:mi></mml:math> -values for both directions (left and right), and then doubling the smaller of the two resulting combined <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>p</mml:mi></mml:math> -values to account for multiple testing. In this work, we show that this multiplicative correction is not always necessary, and give a sufficient and necessary condition under which it can be safely omitted.

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Publication Details

Journal
Statistics & Probability Letters
Published
2026-01-30
DOI
https://doi.org/10.1016/j.spl.2026.110662
Primary Topic
Statistical Methods in Clinical Trials
Type
article
Field-Weighted Citation Impact
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article

Directional replicability: When can the factor of two be omitted

T. Sofer, Jonathan M. Dreyfuss, Vera Djordjilović
Statistics & Probability Letters
Statistical Methods in Clinical Trials
article

Directional replicability: When can the factor of two be omitted

T. Sofer, Jonathan M. Dreyfuss, Vera Djordjilović
article en

Abstract

Directional replicability addresses the question of whether an effect studied across <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>n</mml:mi></mml:math> independent studies is present with the same direction in at least <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>r</mml:mi></mml:math> of them, for <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>r</mml:mi> <mml:mo>≥</mml:mo> <mml:mn>2</mml:mn></mml:math> . When the expected direction of the effect is not specified in advance, the state of the art recommends assessing replicability separately by combining one-sided <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>p</mml:mi></mml:math> -values for both directions (left and right), and then doubling the smaller of the two resulting combined <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>p</mml:mi></mml:math> -values to account for multiple testing. In this work, we show that this multiplicative correction is not always necessary, and give a sufficient and necessary condition under which it can be safely omitted.

Statistics & Probability LettersVol. 233
Brigham and Women's Hospital (US), Joslin Diabetes Center (US), Beth Israel Deaconess Medical Center (US), Harvard University (US), Ca' Foscari University of Venice (IT)
European Commission
Openalex Percentile: Top 75%
Statistical Methods in Clinical Trials
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