Tricuspid Valve Is Transcriptionally Active During Prolonged Pressure Overload, Right‐Sided Heart Failure, and Valve Regurgitation
This project highlights the complexity of heart valve tissues and their transcriptional activity in a sheep model of RHF. It suggests potential therapeutic interventions in heart valve remodeling in pulmonary artery hypertension, RHF, and tricuspid regurgitation. This work highlights the need for further human and model organism research into the dynamic valve cells and genes.
Authors
- Timek Ta
- Magda Piekarska (ORCID: https://orcid.org/0000-0002-9889-3251)
- Aitor Aguirre (ORCID: https://orcid.org/0000-0002-1383-2792)
- Renzo Y. Loyaga‐Rendon (ORCID: https://orcid.org/0000-0002-3441-8355)
- Austin Goodyke (ORCID: https://orcid.org/0000-0003-3989-1026)
- Jeremy W. Prokop (ORCID: https://orcid.org/0000-0002-1818-9695)
- Mason Westgate
- Sanjana Arora
- Manuel K. Rausch
- Boguslaw Gaweda
- Milena Jani
Institutions
- Northwell Health (US)
- Medical University of Silesia (PL)
- West Health (US)
- Corewell Health
- The University of Texas at Austin (US)
- Michigan State University (US)
- University of Rzeszów (PL)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1161/jaha.125.046137
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00