TLR4/NF-κB signaling-mediated neuroinflammation is associated with gut microbiota dysbiosis in a mouse model of Parkinson’s disease
This study demonstrates a key role of the TLR4/NF-κB signaling pathway in the microbiota-gut-brain axis of a rotenone-induced PD mouse model, where gut microbiota dysbiosis exhibits a significant correlation with inflammation induced by TLR4/NF-κB activation.
Authors
- Chen Yang (ORCID: https://orcid.org/0000-0003-1555-1940)
- Xiaoyu Shi (ORCID: https://orcid.org/0009-0002-5893-591X)
- Ruqi Zhang
- Yangyang Wu
- Minghan Tian
- Shengchun Wang
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Linyi People's Hospital (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fimmu.2026.1672241
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00