Single cell profiling reveals GSM-15606 attenuates air pollution-induced inflammation and preserves hippocampal neurogenesis
AirPoll activates divergent inflammatory pathways across hippocampal cell populations and suppresses neurogenesis. Targeting inflammation with GSM-15606 selectively reverses glial but not neural stem cell responses, highlighting cell-type-specific mechanisms and potential therapeutic pathways to mitigate pollution-related cognitive vulnerability. These results support GSM-15606 as a protective agent against AirPoll-induced hippocampal dysfunction and amyloidogenic stress.
Authors
- Michael A. Bonaguidi
- Wynnie Nguyen
- Constantinos Sioutas
- Max A. Thorwald
- Kristina Shkirkova (ORCID: https://orcid.org/0000-0002-9288-4258)
- Mohammad Shariq
- Lei Peng
- Wang Xiang
- Jose Godoy Lugo
- Jonathan N. Levi
- Wanqing Pan
- Caleb E Finch
- Xiran Chen
- William J Mack
- Albina Ibreyeva
Institutions
- University of Southern California (US)
- Broad Center (US)
- Neurological Surgery (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-30
- DOI
- https://doi.org/10.64898/2026.01.27.702094
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- California Institute for Regenerative Medicine
- Cure Alzheimer's Fund
- National Institutes of Health