The D826V point mutation in IREB2 induces lipogenesis in adipose tissues
The <i>Ireb2</i> <sup>D826V/D826V</sup> mutation is linked to the degradation of IREB2, increased expression of FTH1, and iron accumulation. These molecular alterations are associated with elevated protein levels of ACACA, ACLY, FASN, EGR1, and FGFR4, which correlate with enhanced lipid biosynthesis and subsequent weight gain. This study elucidates a link between dysregulated iron storage, mediated via the IREB2-FTH1 axis, and the upregulation of key lipogenic genes, resulting in enhanced lipid biosynthesis. These findings underscore a potential relationship between iron metabolism and obesity, suggesting that iron homeostasis could serve as a valuable target for further mechanistic investigation and therapeutic development in the context of obesity.
Authors
- Jianmei Huang (ORCID: https://orcid.org/0000-0001-5117-7533)
- Chunyu Wu
- Chenyang Wang (ORCID: https://orcid.org/0000-0003-2931-4743)
- Zhenglong Guo
- Jinming Wang
- Yibing Lv
- Junyi Xiao
- Wenke Yang
- Shixiu Liao
Institutions
- China Pharmaceutical University (CN)
- Zhengzhou University (CN)
- Henan Provincial People's Hospital (CN)
- Zhengzhou People's Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fcell.2026.1724485
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Henan Province