Elucidating the functional dynamics of DNASE1L2 intron retention in tuberculosis progression
These findings identify DNASE1L2-IR splicing dynamics as a novel biomarker for monitoring TB progression and reveal a host-defense mechanism in which DNASE1L2-IR regulates M. tuberculosis DNA degradation to modulate TB progression.
Authors
- Huiyu Zhong
- Hongli Lai (ORCID: https://orcid.org/0000-0002-7146-3518)
- Ye Hu (ORCID: https://orcid.org/0000-0001-7255-5409)
- Jiao Yang (ORCID: https://orcid.org/0000-0002-5007-9154)
- Haohao Dong
- Mengyuan Lyu
- Hongxia Ruan
- Yang Liu
- Hao Chen
- Yanjun Si
- Tangyuheng Liu
- Xiaodi Tang
- Jian Zhou
- Lu Niu
Institutions
- Tulane University (US)
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Sichuan Research Center of New Materials (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1097/cm9.0000000000003974
- Primary Topic
- RNA and protein synthesis mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00