Parameter-efficient fine-tuning enables scalable transfer of regulatory sequence models to novel contexts
Our framework offers a scalable and practical solution for extending large sequence models to novel biological contexts, enabling mechanistic insight into gene regulation and variant effects.
Authors
- Johannes Linder (ORCID: https://orcid.org/0000-0003-2134-7292)
- Han Yuan (ORCID: https://orcid.org/0000-0002-9636-9376)
- David R. Kelley (ORCID: https://orcid.org/0000-0001-7782-3548)
Institutions
- ISCO International (United States) (US)
Publication Details
- Journal
- Genome biology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1186/s13059-026-03935-0
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00