The hemodynamic impact of congenital heart diseases during fetal-to-neonatal transition: an in-silico investigation

This study introduces a mathematical model that simulates the hemodynamic impact of congenital heart disease (CHD) during the fetal-to-neonatal transition, focusing on ventricular septal defect (VSD) and transposition of the great arteries (TGA). By integrating a one-fiber heart model and oxygen and carbon dioxide dynamics, the model gives a prediction of critical clinical parameters like flow, pressure, and oxygen saturation. This mathematical model has a potential to serve as non-invasive tool, providing valuable insights for prenatal planning and postnatal management, helping guide timely interventions for newborns affected by CHD.