Integrative proteogenomics maps multifactorial aetiology, progression and therapeutic vulnerabilities in gastric cancer
This proteogenomic framework defines exposure-informed and microbiome-informed gastric cancer subtypes, providing a molecular schema for patient stratification, prevention and actionable therapeutic vulnerabilities.
Authors
- Ze-Shiang Lin
- Yutai Wang
- Chi-Ya Shen
- Tzu-Chan Hong
- Wen-Hung Hsu
- Juanilita T. Waniwan
- L. Chen
- Yan-Si Chen
- Min-Shu Hsieh
- Chang-Wei Yeh
- Chia‐Li Han (ORCID: https://orcid.org/0000-0003-4644-5892)
- Yan-Ming Chen
- Yk Wang
- Wenyi Liu (ORCID: https://orcid.org/0000-0002-7021-5854)
- Yi‐Ju Chen
- Ya‐Hsuan Chang (ORCID: https://orcid.org/0000-0002-0743-4819)
- Hsuan‐Yu Chen
- Hsiang-En Hsu
- Ming-Tsan Lin
- Po-Chu Lee
- Ching-Chun Li
- I-Chen Wu
- Sung-Liang Yu
- Yi-Jing Hsiao
- Yin-Chen Hsu
- Chia-Tung Shun
- Yu-Teng Jheng
- Jyh-Ming Liou
- Jyun-Hong Lin
- Yu-Ju Chen
- Song-Wei Wang
- Ying-Chieh Ko
- Rodrigo Espinoza Silva
- Ming-Shiang Wu
- Hao Fang
- Wen-Hsin Chang
- Chia-Yu Wang
- Deng-Chyang Wu
- I-Rue Lai
Institutions
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Medical University (TW)
- National Chung Hsing University (TW)
- National Health Research Institutes (TW)
- National Taiwan University (TW)
- National Tsing Hua University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Institute of Information Science, Academia Sinica (TW)
- National Center for High-Performance Computing (TW)
- National Taiwan University Hospital (TW)
- Institute of Statistical Science, Academia Sinica (TW)
- Institute of Chemistry, Academia Sinica (TW)
- Taipei Medical University (TW)
- Academia Sinica (TW)
- National Yang Ming Chiao Tung University (TW)
Publication Details
- Journal
- Gut
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1136/gutjnl-2025-337247
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00