Potential Anti‐Aging Effects of a Dietary Supplement From the Algal‐Derived Omega‐3 <scp>DHA</scp> in Aged <scp>SAMP</scp> 8 Mice

This study investigated the anti-aging effects of algal Omega3-DHA in senescence-accelerated mice (SAM). Male and female SAMP8 mice (3 months old) were divided into a control group and four experimental groups (1× or 2× algal Omega3-DHA, with/without phospholipids). The mice were orally administered test samples dissolved in corn oil daily for 13 weeks. Aging scores were significantly lower in male mice across all experimental groups and in female mice in the phosphatidylcholine (PC) and phosphatidylserine (PS) (<i>p</i> < 0.05) groups. Learning and memory improved significantly in all the experimental groups (<i>p</i> < 0.05). Brain biomarkers of aging, including 8-hydroxy-2'-deoxyguanosine (8-OHdG), thiobarbituric acid-reactive substances (TBARS), protein carbonyl content, and β-amyloid (Aβ) protein, were significantly reduced, while liver antioxidant enzyme activities, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), were increased in the PC and PS groups (<i>p</i> < 0.05). Additionally, survival times were extended in both male and female mice compared to controls. No adverse effects were observed in terms of body weight or activity level. In summary, algal Omega3-DHA supplementation improved cognitive performance, enhanced antioxidant defenses, reduced aging markers, and delayed aging in SAM mice, highlighting its potential as a promising anti-aging strategy.