Sex and All-Cause Mortality in the US, 1999 to 2018
In this cohort study of adult NHANES participants, after accounting for a wide range of risk factors, the sex gap in mortality remained for most causes of mortality, suggesting there may be intrinsic biological factors (eg, sex hormones, chromosomes, immune response) associated with sex differences in mortality. Further research should investigate the effects of sex-linked biological factors on mortality.
Authors
- Sarah S. Jackson (ORCID: https://orcid.org/0000-0001-6986-8842)
- Hormuzd A. Katki (ORCID: https://orcid.org/0000-0003-2002-0095)
- Julia M. Francis (ORCID: https://orcid.org/0009-0007-7049-771X)
- Barry I. Graubard
Institutions
- National Institutes of Health (US)
- National Cancer Institute (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.56299
- Citations
- 1
- Primary Topic
- Sex and Gender in Healthcare
- Type
- article
- Field-Weighted Citation Impact
- 41.85
Funders
- National Institutes of Health
- National Cancer Institute