Photocatalytic Copper-Promoted Heptafluoroisopropylation of Arylsulfonium Salts with AgCF(CF <sub>3</sub> ) <sub>2</sub>
A copper-promoted synthesis of heptafluoroisopropylarenes through visible-light-induced coupling of arylsulfonium salts with AgCF(CF<sub>3</sub>)<sub>2</sub> is presented. The reaction, conducted at room temperature under 420 nm LED irradiation, efficiently converted different types of arylsulfonium salts to the corresponding heptafluoroisopropylarenes in good yields, taming the light-sensitive silver reagent while exhibiting broad functional group tolerance and excellent chemoselectivity. This protocol was also feasible for the introduction of the CF(CF<sub>3</sub>)<sub>2</sub> moiety into drug molecules, supplying an advantageous method for late-stage molecular functionalization.
Authors
- Jianhua Zhang (ORCID: https://orcid.org/0000-0001-7844-6035)
- Jiang-Yu Li
Institutions
- Wuhan University of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1021/acs.orglett.6c00007
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00