Dynamics of Intact and Defective Human Immunodeficiency Virus Type 1 (HIV-1) Proviruses During Decades of Suppressive Antiretroviral Treatment in Young Adults With Perinatal HIV
Achieving VS by 1 year of age in perinatal HIV-1 infection results in substantially smaller HIV-1 intact reservoirs by age 5, with effects sustained through young adulthood. Additionally, sex-based differences, larger intact reservoirs and increases in defective proviruses in females, underscore the need for tailored ART-free remission and cure strategies for this population.
Authors
- Adit Dhummakupt
- Joseph Szewczyk (ORCID: https://orcid.org/0000-0003-0540-3274)
- Priya Khetan (ORCID: https://orcid.org/0000-0001-5688-2071)
- Wendy Yu (ORCID: https://orcid.org/0000-0001-5967-2352)
- Kunjal Patel
- Russell B Van Dyke
- Deborah Persaud
- Sandra Burchett
Institutions
- Tulane University (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Cancer Research And Biostatistics (US)
- Boston Children's Museum (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1093/infdis/jiag045
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00