SENP6-mediated desumoylation of SMAD5 regulates osteogenic fate in periodontal ligament stem cells
The SENP6-SMAD5-SOX2 axis is a critical regulator of early PDLSC osteogenic commitment. Pharmacological inhibition of SENP6 offers a promising therapeutic strategy for restoring bone regeneration in inflammatory environments.
Authors
- C. Liu
- Wenjia Wei
- Bo Ji (ORCID: https://orcid.org/0009-0003-6951-5248)
- Hong Jin
- Yuzhu Wang (ORCID: https://orcid.org/0000-0003-0449-2973)
- Huawei Xie
Institutions
- Harbin Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Tongren Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1186/s40001-026-03995-9
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00