A real-world evidence of sputum microbiota alterations and their association with oncogenomic changes and response to targeted therapies in patients with lung cancer
We demonstrated that opportunistic pathogens exhibited higher infection rates in patients with TP53-mutated, TMB-H, and non-EGFR-mutated tumors. Microbial infection in patients with EGFR mutations might be an influencing factor that weakens the therapeutic efficacy.
Authors
- Zu-Lu Ye
- Wen-Na Xu (ORCID: https://orcid.org/0009-0006-9312-8506)
- Xin-hua Yang
- Cai-Yun He
- Ting Li
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1186/s12866-026-04773-7
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00