Association between brain volume and depression in Alzheimer's disease: Neuroimaging insights

Hippocampal atrophy significantly mediates the relationship between depression and AD, suggesting targeted interventions may enhance patient outcomes.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2026-01-29
DOI
https://doi.org/10.1002/alz.71120
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Association between brain volume and depression in Alzheimer's disease: Neuroimaging insights

Xiaoyang Lei, Jiaxin Yang, Chao Tang, Dian He et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Association between brain volume and depression in Alzheimer's disease: Neuroimaging insights

Xiaoyang Lei, Jiaxin Yang, Chao Tang, Dian He, Ming Zhang, Yi Chen, Xiaoxue Peng
article en

Abstract

Hippocampal atrophy significantly mediates the relationship between depression and AD, suggesting targeted interventions may enhance patient outcomes.

Alzheimer s & DementiaVol. 22(2)
Guiyang Medical University (CN), Affiliated Hospital of Guizhou Medical University (CN)
Eli Lilly and Company, Yale University, University of Southern California, Vanderbilt University, University of Pennsylvania, Emory University, Cure Alzheimer's Fund, University of Washington, Johns Hopkins University, University of Pittsburgh, Rush University, Health Commission of Guizhou Province, York University, National Institutes of Health, Genentech, University of California, Davis, University of California, San Diego, University of California, San Francisco, University of California, Irvine, Avid Radiopharmaceuticals
Openalex Percentile: Top 74%
Dementia and Cognitive Impairment Research
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