Arsenic trioxide-induced acute kidney injury: OPA1- and Drp1-mediated mitochondrial dynamics imbalance, PINK1/Parkin-dependent mitophagy, and Chuanhuang Fang III
The pathogenesis of clinical-dose ATO-induced AKI involves OPA1- and Drp1-mediated mitochondrial dynamics imbalance and PINK1/Parkin-dependent mitophagy in renal tubular epithelial cells, CHF ameliorated this injury by restoring mitochondrial quality control, highlighting its therapeutic potential against AI-AKI.
Authors
- Peiji Wang
- Xuezhong Gong
- Yifan Zhang
- Zicong Wu
- Xingyu Deng
- Zhiyong Song
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fmolb.2026.1778855
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality